Back to Search
Start Over
A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength.
- Source :
-
Cell reports [Cell Rep] 2021 Aug 03; Vol. 36 (5), pp. 109467. - Publication Year :
- 2021
-
Abstract
- Recent studies have demonstrated that protein translation can be regulated by spontaneous excitatory neurotransmission. However, the impact of spontaneous neurotransmitter release on gene transcription remains unclear. Here, we study the effects of the balance between inhibitory and excitatory spontaneous neurotransmission on brain-derived neurotrophic factor (BDNF) regulation and synaptic plasticity. Blockade of spontaneous inhibitory events leads to an increase in the transcription of Bdnf and Npas4 through altered synaptic calcium signaling, which can be blocked by antagonism of NMDA receptors (NMDARs) or L-type voltage-gated calcium channels (VGCCs). Transcription is bidirectionally altered by manipulating spontaneous inhibitory, but not excitatory, currents. Moreover, blocking spontaneous inhibitory events leads to multiplicative downscaling of excitatory synaptic strength in a manner that is dependent on both transcription and BDNF signaling. These results reveal a role for spontaneous inhibitory neurotransmission in BDNF signaling that sets excitatory synaptic strength at rest.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Basic Helix-Loop-Helix Transcription Factors genetics
Basic Helix-Loop-Helix Transcription Factors metabolism
Brain-Derived Neurotrophic Factor metabolism
Calcium Signaling
Excitatory Postsynaptic Potentials physiology
Inhibitory Postsynaptic Potentials physiology
Neural Inhibition physiology
Neurons metabolism
RNA, Messenger genetics
RNA, Messenger metabolism
Rats, Sprague-Dawley
Transcription, Genetic
Rats
Brain-Derived Neurotrophic Factor genetics
Gene Expression Regulation
Rest
Synapses metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2211-1247
- Volume :
- 36
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cell reports
- Publication Type :
- Academic Journal
- Accession number :
- 34348149
- Full Text :
- https://doi.org/10.1016/j.celrep.2021.109467