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PVA based nanofiber containing cellulose modified with graphitic carbon nitride/nettles/trachyspermum accelerates wound healing.
- Source :
-
Biotechnology progress [Biotechnol Prog] 2021 Nov; Vol. 37 (6), pp. e3200. Date of Electronic Publication: 2021 Aug 12. - Publication Year :
- 2021
-
Abstract
- Today, bacterial cellulose has received a great deal of attention for its medical applications due to its unique structural properties such as high porosity, good fluid uptake, good strength, and biocompatibility. This study aimed to fabricate and study bacterial cellulose/graphitic carbon nitride/nettles/trachyspermum nanocomposite by immersion and PVA/BC/g-C <subscript>3</subscript> N <subscript>4</subscript> /nettles/trachyspermum nanofiber by electrospinning method as a wound dressing. The g-C <subscript>3</subscript> N <subscript>4</subscript> and g-C <subscript>3</subscript> N <subscript>4</subscript> solution were synthesized and then were characterized using Fourier transform infrared, X-ray diffraction, Zeta Potential, and scanning electronic microscope analyzes. Also, the antibacterial properties of the synthesized materials were proved by gram-positive and gram-negative bacteria using the minimum inhibitory concentration method. Besides, the toxicity, migration, and cell proliferation results of the synthesized materials on NIH 3T3 fibroblasts were evaluated using MTT and scratch assays and showed that the BC/PVA/g-C <subscript>3</subscript> N <subscript>4</subscript> /nettles/trachyspermum composite not only had no toxic effect on cells but also contributed to cell survival, cell migration, and proliferation has done. To evaluate the mechanical properties, a tensile strength test was performed on PVA/BC/g-C <subscript>3</subscript> N <subscript>4</subscript> /nettles/trachyspermum nanofibers, and the results showed good strength of the nanocomposite. In addition, in vivo assay, the produced nanofibers were used to evaluate wound healing, and the results showed that these nanofibers were able to accelerate the wound healing process so that after 14 days, the wound healing percentage showed 95%. Therefore, this study shows that PVA/BC/g-C <subscript>3</subscript> N <subscript>4</subscript> /nettles/trachyspermum nanofibers effectively inhibit bacterial growth and accelerate wound healing.<br /> (© 2021 American Institute of Chemical Engineers.)
- Subjects :
- Animals
Apiaceae chemistry
Bacteria chemistry
Bacteria drug effects
Cell Survival drug effects
Mice
Microbial Sensitivity Tests
NIH 3T3 Cells
Nanofibers chemistry
Plant Extracts chemistry
Plant Extracts pharmacology
Polyvinyl Alcohol chemistry
Stachys chemistry
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Bandages
Cellulose chemistry
Cellulose pharmacology
Graphite chemistry
Graphite pharmacology
Nitrogen Compounds chemistry
Nitrogen Compounds pharmacology
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6033
- Volume :
- 37
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Biotechnology progress
- Publication Type :
- Academic Journal
- Accession number :
- 34346569
- Full Text :
- https://doi.org/10.1002/btpr.3200