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Progressive Cytopenia Developing during Treatment of Cryptococcosis in a Patient with HIV Infection and Bone Marrow Cryptococcal Infection.
- Source :
-
Internal medicine (Tokyo, Japan) [Intern Med] 2022 Jan 15; Vol. 61 (2), pp. 257-261. Date of Electronic Publication: 2021 Jul 30. - Publication Year :
- 2022
-
Abstract
- Cytopenia is a common complication in patients with human immunodeficiency virus (HIV) infection. Identifying the cause is demanding because of the wide range of possible diagnoses. We herein report an HIV-infected patient with disseminated cryptococcosis involving multiple organs including the blood, brain, lungs, and bone marrow, who developed progressive pancytopenia after initiation of anti-fungal treatment with liposomal amphotericin-B (L-AMB) and flucytosine (5FC). The pancytopenia persisted despite early 5FC discontinuation. A bone marrow biopsy revealed cryptococcal infiltration and the blood examination findings recovered quickly after resuming L-AMB. Thus, this HIV-infected patient's pathological findings and clinical course suggested that the primary cause of the pancytopenia was bone marrow cryptococcosis.
- Subjects :
- Antifungal Agents therapeutic use
Bone Marrow
Flucytosine therapeutic use
Humans
Cryptococcosis complications
Cryptococcosis diagnosis
Cryptococcosis drug therapy
Cryptococcus neoformans
HIV Infections complications
HIV Infections drug therapy
Meningitis, Cryptococcal complications
Meningitis, Cryptococcal diagnosis
Meningitis, Cryptococcal drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7235
- Volume :
- 61
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Internal medicine (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 34334563
- Full Text :
- https://doi.org/10.2169/internalmedicine.7282-21