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Anorexia, pain and peripheral neuropathy are associated with a decrease in quality of life in patients with advanced pancreatic cancer receiving outpatient chemotherapy - a retrospective observational study.
- Source :
-
Journal of pharmaceutical health care and sciences [J Pharm Health Care Sci] 2021 Aug 02; Vol. 7 (1), pp. 27. Date of Electronic Publication: 2021 Aug 02. - Publication Year :
- 2021
-
Abstract
- Background: Cancer chemotherapy usually improves clinical outcomes in patients with advanced pancreatic cancer (APC), but can also cause moderate-to-severe adverse events (AEs). We investigated the relationship between moderate-to-severe AEs and quality of life (QOL) in patients with APC who received outpatient chemotherapy.<br />Methods: We recruited APC patients who received outpatient chemotherapy in Gifu University Hospital between September 2017 and December 2018. Adverse events related to chemotherapy were assessed by a pharmacist collaborating with a physician using common terminology criteria for AEs (CTCAE) ver 4.0, and QOL of patients was self-assessed by patients using the five-level EuroQol five-dimensional questionnaire (EQ-5D-5L Japanese edition 2). Associations between the EQ-5D-5L utility value and serious AEs were assessed using proportional odds logistic regression.<br />Results: A total of 59 patients who received 475 chemotherapy cycles were included. The proportional odds logistic regression indicated that grade ≥ 2 anorexia, pain and peripheral neuropathy were significantly correlated with a decreased EQ-5D-5L utility value. Pharmaceutical intervention for these AEs significantly improved the patients' EQ-5D-5L utility value.<br />Conclusions: Anorexia, pain and peripheral neuropathy were significantly associated with a decrease in QOL. It is assumed that appropriate pharmaceutical intervention with particular emphasis on these AEs can improve the QOL of pancreatic cancer patients receiving outpatient chemotherapy.<br /> (© 2021. The Author(s).)
Details
- Language :
- English
- ISSN :
- 2055-0294
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of pharmaceutical health care and sciences
- Publication Type :
- Academic Journal
- Accession number :
- 34334136
- Full Text :
- https://doi.org/10.1186/s40780-021-00210-1