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Obesity, POMC, and POMC-processing Enzymes: Surprising Results From Animal Models.
- Source :
-
Endocrinology [Endocrinology] 2021 Dec 01; Vol. 162 (12). - Publication Year :
- 2021
-
Abstract
- Peptides derived from proopiomelanocortin (POMC) are well-established neuropeptides and peptide hormones that perform multiple functions, including regulation of body weight. In humans and some animals, these peptides include α- and β-melanocyte-stimulating hormone (MSH). In certain rodent species, no β-MSH is produced from POMC because of a change in the cleavage site. Enzymes that convert POMC into MSH include prohormone convertases (PCs), carboxypeptidases (CPs), and peptidyl-α-amidating monooxygenase (PAM). Humans and mice with inactivating mutations in either PC1/3 or carboxypeptidase E (CPE) are obese, which was assumed to result from defective processing of POMC into MSH. However, recent studies have shown that selective loss of either PC1/3 or CPE in POMC-expressing cells does not cause obesity. These findings suggest that defects in POMC processing cannot alone account for the obesity observed in global PC1/3 or CPE mutants. We propose that obesity in animals lacking PC1/3 or CPE activity depends, at least in part, on deficient processing of peptides in non-POMC-expressing cells either in the brain and/or the periphery. Genetic background may also contribute to the manifestation of obesity.<br /> (© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.)
- Subjects :
- Animals
Brain metabolism
Disease Models, Animal
Humans
Mice
Mice, Obese
Obesity metabolism
Obesity pathology
Proprotein Convertase 2 physiology
Carboxypeptidases physiology
Mixed Function Oxygenases physiology
Multienzyme Complexes physiology
Obesity etiology
Pro-Opiomelanocortin physiology
Proprotein Convertases physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7170
- Volume :
- 162
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 34333593
- Full Text :
- https://doi.org/10.1210/endocr/bqab155