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Extraction of the antioxidant phytocomplex from wine-making by-products and sustainable loading in phospholipid vesicles specifically tailored for skin protection.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Oct; Vol. 142, pp. 111959. Date of Electronic Publication: 2021 Jul 29. - Publication Year :
- 2021
-
Abstract
- The present study is aimed at valorizing grape pomace, one of the most abundant winery-making by-products of the Mediterranean area, through the extraction of the main bioactive compounds from the skin of grape pomace and using them to manufacture innovative nanoformulations capable of both avoiding skin damages and promoting skincare. The phytochemicals were recovered through maceration in hydroethanolic solution. Catechin, quercetin, fisetin and gallic acid, which are known for their antioxidant power, were detected as the main compounds of the extract. Liposomes and phospholipid vesicles modified with glycerol or Montanov 82® or a combination of both, were used as carriers for the extract. The vesicles were small (~183 nm), slightly polydispersed (PI ≥ 0.28), and highly negatively charged (~-50 mV). The extract was loaded in high amounts in all vesicles (~100%) irrespective of their composition. The antioxidant activity of the extract, measured by using the DPPH (2,2-Diphenyl-1-picrylhydrazyl) test, was 84 ± 1%, and slightly increased when loaded into the vesicles (~89%, P < 0.05). The grape pomace extract loaded vesicles were highly biocompatible and able to protect fibroblasts (3T3) from the oxidative stress induced by hydrogen peroxide.<br /> (Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Subjects :
- 3T3 Cells
Animals
Antioxidants administration & dosage
Antioxidants isolation & purification
Fibroblasts drug effects
Fibroblasts pathology
Hydrogen Peroxide
Liposomes
Mice
Oxidative Stress drug effects
Particle Size
Phospholipids chemistry
Phytochemicals administration & dosage
Phytochemicals isolation & purification
Phytochemicals pharmacology
Plant Extracts administration & dosage
Plant Extracts chemistry
Skin pathology
Wine analysis
Antioxidants pharmacology
Plant Extracts pharmacology
Skin drug effects
Vitis chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 142
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 34333288
- Full Text :
- https://doi.org/10.1016/j.biopha.2021.111959