Back to Search Start Over

Pallidal and Cortical Oscillations in Freely Moving Patients With Dystonia.

Authors :
Averna A
Arlotti M
Rosa M
Chabardès S
Seigneuret E
Priori A
Moro E
Meoni S
Source :
Neuromodulation : journal of the International Neuromodulation Society [Neuromodulation] 2023 Dec; Vol. 26 (8), pp. 1661-1667. Date of Electronic Publication: 2022 Feb 15.
Publication Year :
2023

Abstract

Objectives: To evaluate the correlation between the pallidal local field potentials (LFPs) activity and the cortical oscillations (at rest and during several motor tasks) in two freely moving patients with generalized dystonia and pallidal deep brain stimulation (DBS).<br />Materials and Methods: Two women with isolated generalized dystonia were selected for bilateral globus pallidus internus (GPi) DBS. After the electrodes' implantation, cortical activity was recorded by a portable electroencephalography (EEG) system simultaneously with GPi LFPs activity, during several motor tasks, gait, and rest condition. Recordings were not performed during stimulation. EEG and LFPs signals relative to each specific movement were coupled together and grouped in neck/upper limbs movements and gait. Power spectral density (PSD), EEG-LFP coherence (through envelope of imaginary coherence operator), and 1/f exponent of LFP-PSD background were calculated.<br />Results: In both patients, the pallidal LFPs PSD at rest was characterized by prominent 4-12 Hz activity. Voluntary movements increased activity in the theta (θ) band (4-7 Hz) compared to rest, in both LFPs and EEG signals. Gait induced a drastic raise of θ activity in both patients' pallidal activity, less marked for the EEG signal. A coherence peak within the 8-13 Hz range was found between pallidal LFPs and EEG recorded at rest.<br />Conclusions: Neck/upper limbs voluntary movements and gait suppressed the GPi-LFPs-cortical-EEG coherence and differently impacted both EEG and LFPs low frequency activity. These findings suggest a selective modulation of the cortico-basal ganglia network activity in dystonia.<br /> (Copyright © 2022. Published by Elsevier Inc.)

Details

Language :
English
ISSN :
1525-1403
Volume :
26
Issue :
8
Database :
MEDLINE
Journal :
Neuromodulation : journal of the International Neuromodulation Society
Publication Type :
Academic Journal
Accession number :
34328685
Full Text :
https://doi.org/10.1111/ner.13503