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Increased interleukin-17A-producing γδT cells predict favorable survival in elderly patients with LUAD and LUSC.
- Source :
-
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Nov; Vol. 147 (11), pp. 3289-3298. Date of Electronic Publication: 2021 Jul 29. - Publication Year :
- 2021
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Abstract
- Purpose: Aging is closely related to the occurrence of many diseases, including cancer, and involves changes in the immune microenvironment. γδT cells are important components of resident lymphocytes in mucosal tissues. However, little is known about the effects that the aged lung has on γδT cells and their prognostic significance in non-small cell lung cancer.<br />Methods: In the current study, the expression of γδTCR and IL-17A was measured by immunohistochemistry in paraffin-embedded lung tissues from 168 patients with adenocarcinoma (LUAD) and 144 patients with squamous cell carcinoma (LUSC). Furthermore, gene transcription patterns in LUAD and LUSC tumors and normal controls were extracted from TCGA and GTEx databases and were analyzed.<br />Results: High frequency of γδT cells was observed in patients with LUAD and LUSC, whereas the levels of CD4 + T cells, CD8 + T cells and CD56 + cells were decreased. Elevated γδT cells in tumors were mainly IL-17A-releasing γδT17 cells, which were found to be enriched in aged patients. High γδT cell levels positively corelated with the overall survival (OS) of patients, especially the 5-year OS in the elderly. Further analysis of gene transcription patterns indicated that increased expression of LTBR, HES1, RORC, CCR6, IL1, and IL23A may contribute to the transformation of the tumor microenvironment in a manner conducive to γδT17 cell development and differentiation. Finally, gene analysis between different age groups revealed that the expression of CCR6 and IL7 in LUAD, as well as Hes1, IL7, and IL23A in LUSC, were remarkably higher in elderly (age ≥ 60 years) than in younger individuals (age < 60 years).<br />Conclusion: Our findings suggest that intrinsic alterations in the aging lung lead to γδT17 cell enrichment, which subsequently may exert anti-tumor effects in the elderly.<br /> (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Adenocarcinoma of Lung mortality
Adult
Age Factors
Aged
Aged, 80 and over
Carcinoma, Squamous Cell mortality
Case-Control Studies
Humans
Interleukin-17 biosynthesis
Lung Neoplasms mortality
Middle Aged
Adenocarcinoma of Lung immunology
Carcinoma, Squamous Cell immunology
Interleukin-17 immunology
Intraepithelial Lymphocytes immunology
Lung Neoplasms immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1335
- Volume :
- 147
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of cancer research and clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 34327570
- Full Text :
- https://doi.org/10.1007/s00432-021-03742-z