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Pseudoboehmite as a drug delivery system for acyclovir.
- Source :
-
Scientific reports [Sci Rep] 2021 Jul 29; Vol. 11 (1), pp. 15448. Date of Electronic Publication: 2021 Jul 29. - Publication Year :
- 2021
-
Abstract
- Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of the low permeability across the gastrointestinal membrane. The use of nanoparticles of pseudoboehmite as a drug delivery system in vitro assays is a promising approach to further the permeability of acyclovir release. Here we report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles, using the sol-gel method, as a drug delivery system to improve the systemic bioavailability of acyclovir. The presence of pseudoboehmite nanoparticles were verified by infrared spectroscopy, transmission electron microscopy, and X-ray diffraction techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content by 4.6 times in the plasma of Wistar rats after 4 h administration. We determined that the toxicity of pseudoboehmite is low up to 10 mg/mL, in gel and the dried pseudoboehmite nanoparticles.<br /> (© 2021. The Author(s).)
- Subjects :
- Acyclovir blood
Acyclovir pharmacokinetics
Administration, Oral
Aluminum Hydroxide pharmacology
Aluminum Oxide pharmacology
Animals
Antiviral Agents blood
Antiviral Agents pharmacokinetics
Biological Availability
Caco-2 Cells
Cell Survival drug effects
Drug Liberation
Herpes Simplex drug therapy
Herpes Simplex virology
Humans
Models, Animal
Rats
Rats, Wistar
Simplexvirus drug effects
Acyclovir administration & dosage
Aluminum Hydroxide chemistry
Aluminum Oxide chemistry
Antiviral Agents administration & dosage
Drug Delivery Systems methods
Nanogels chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 34326377
- Full Text :
- https://doi.org/10.1038/s41598-021-94325-y