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Interaction between intestinal microbiota and tumour immunity in the tumour microenvironment.
- Source :
-
Immunology [Immunology] 2021 Nov; Vol. 164 (3), pp. 476-493. Date of Electronic Publication: 2021 Sep 26. - Publication Year :
- 2021
-
Abstract
- In recent years, an increasing number of studies have reported that intestinal microbiota have an important effect on tumour immunity by affecting the tumour microenvironment (TME). The intestinal microbiota are closely associated with various immune cells, such as T lymphocytes, natural killer cells (NK cells) and macrophages. Some bacteria, such as Akkermansia muciniphila (A. muciniphila) and Lactobacillus reuteri (L. reuteri), have been shown to improve the effect of tumour immunity. Furthermore, microbial imbalance, such as the increased abundance of Fusobacterium nucleatum (F. nucleatum) and Helicobacter hepaticus (H. hepaticus), generally causes tumour formation and progression. In addition, some microbiota also play important roles in tumour immunotherapy, especially PD-L1-related therapies. Therefore, what is the relationship between these processes and how do they affect each other? In this review, we summarize the interactions and corresponding mechanisms among the intestinal microbiota, immune system and TME to facilitate the research and development of new targeted drugs and provide new approaches to tumour therapy.<br /> (© 2021 The Authors. Immunology published by John Wiley & Sons Ltd.)
- Subjects :
- Animals
B7-H1 Antigen antagonists & inhibitors
Disease Models, Animal
Disease Progression
Dysbiosis microbiology
Dysbiosis pathology
Fusobacterium nucleatum immunology
Gastrointestinal Microbiome drug effects
Helicobacter hepaticus immunology
Humans
Immune Checkpoint Inhibitors pharmacology
Immune Checkpoint Inhibitors therapeutic use
Killer Cells, Natural immunology
Macrophages immunology
Neoplasms drug therapy
Neoplasms microbiology
Neoplasms pathology
T-Lymphocytes immunology
Tumor Microenvironment drug effects
Dysbiosis immunology
Gastrointestinal Microbiome immunology
Neoplasms immunology
Tumor Microenvironment immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2567
- Volume :
- 164
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34322877
- Full Text :
- https://doi.org/10.1111/imm.13397