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Corneal inflammatory cell infiltration predicts disease activity in chronic inflammatory demyelinating polyneuropathy.
- Source :
-
Scientific reports [Sci Rep] 2021 Jul 26; Vol. 11 (1), pp. 15150. Date of Electronic Publication: 2021 Jul 26. - Publication Year :
- 2021
-
Abstract
- The assessment of disease activity is fundamental in the management of chronic inflammatory demyelinating polyneuropathy (CIDP). Previous studies with small patient numbers found an increase of corneal immune cell infiltrates as a potential marker of inflammation in patients with CIDP. However, its clinical relevance remained unclear. The present study aimed to determine whether the amount of corneal inflammatory cells (CIC) measured by corneal confocal microscopy (CCM) detects disease activity in CIDP. CIC were measured in 142 CCM-investigations of 97 CIDP-patients. Data on clinical disease activity, disability (INCAT-ODSS) and need for therapy escalation at the timepoint of CCM, 3 and 6 months later were analyzed depending CIC-count. Pathological spontaneous activity during electromyography was examined as another possible biomarker for disease activity in comparison to CIC-count. An increased CIC-count at baseline was found in patients with clinical disease activity and disability progression in the following 3-6 months. An increase to more than 25 CIC/mm <superscript>2</superscript> had a sensitivity of 0.73 and a specificity of 0.71 to detect clinical disease activity and a sensitivity of 0.77 and a specificity of 0.64 to detect disability progression (increasing INCAT-ODSS) in the following 6 months. An increase to more than 50 CIC/mm <superscript>2</superscript> had a sensitivity of about 0.51 and a specificity of 0.91 to detect clinical disease activity and a sensitivity of 0.53 and a specificity of 0.80 to detect disability progression. CIC count is a non-invasive biomarker for the detection of disease activity in the following 6 months in CIDP.<br /> (© 2021. The Author(s).)
- Subjects :
- Adult
Aged
Cohort Studies
Cornea immunology
Cornea pathology
Disease Progression
Electromyography
Female
Humans
Male
Microscopy, Confocal methods
Middle Aged
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating immunology
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating physiopathology
Prognosis
Prospective Studies
Cornea diagnostic imaging
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 34312451
- Full Text :
- https://doi.org/10.1038/s41598-021-94605-7