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Very delayed sinus arrest during complete remission of diffuse large B-cell lymphoma invading right atrium.
- Source :
-
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir [Turk Kardiyol Dern Ars] 2021 Jul; Vol. 49 (5), pp. 414-418. - Publication Year :
- 2021
-
Abstract
- Diffuse large B-cell lymphoma (DLBCL)-associated arrhythmias may be due to cardiac involvement or may be chemotherapy-induced. There have been no reports of significant arrhythmias with normal cardiac function occurring during the complete remission of DLBCL. A 57-year-old female, who had had no history of abnormal electrocardiograms (ECGs) in annual medical checkups, was admitted to our hospital because of low-grade fever, night sweats, and weight loss. On admission, ECG revealed a variable rhythm consisting of sinus beats and occasional escape beats. Computed tomography and 18F-fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) revealed two masses in the right atrium (RA) and the uterus. Total hysterectomy was performed, and pathological findings were consistent with diffuse large B-cell lymphoma (DLBCL). Chemotherapy (R-CHOP) was initiated. After two chemotherapy cycles, RA tumors disappeared, and bradyarrhythmia simultaneously converted to sinus rhythm without antiarrhythmic drug therapy. Six months after completion of chemotherapy, FDG-PET/CT revealed negative uptake in the RA and the uterus. The patient attained complete remission of DLBCL, but ECG showed bradycardia because of sinus arrest. Our case suggests that DLBCL-induced arrhythmia can occur even after its remission and should be monitored.
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols therapeutic use
Bradycardia etiology
Cyclophosphamide therapeutic use
Doxorubicin therapeutic use
Electrocardiography
Female
Fluorodeoxyglucose F18
Heart Atria diagnostic imaging
Heart Atria pathology
Heart Neoplasms diagnostic imaging
Heart Neoplasms pathology
Heart Neoplasms therapy
Humans
Lymphoma, Large B-Cell, Diffuse diagnostic imaging
Lymphoma, Large B-Cell, Diffuse pathology
Lymphoma, Large B-Cell, Diffuse therapy
Middle Aged
Neoplasm Invasiveness
Positron Emission Tomography Computed Tomography
Prednisone therapeutic use
Remission Induction
Rituximab therapeutic use
Uterine Neoplasms diagnostic imaging
Uterine Neoplasms therapy
Vincristine therapeutic use
Heart Neoplasms complications
Lymphoma, Large B-Cell, Diffuse complications
Sinus Arrest, Cardiac etiology
Uterine Neoplasms complications
Subjects
Details
- Language :
- English
- ISSN :
- 1308-4488
- Volume :
- 49
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
- Publication Type :
- Report
- Accession number :
- 34308876
- Full Text :
- https://doi.org/10.5543/tkda.2021.57474