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Cancer chemopreventive role of fisetin: Regulation of cell signaling pathways in different cancers.
- Source :
-
Pharmacological research [Pharmacol Res] 2021 Oct; Vol. 172, pp. 105784. Date of Electronic Publication: 2021 Jul 22. - Publication Year :
- 2021
-
Abstract
- It is becoming progressively more understandable that pharmaceutical targeting of drug-resistant cancers is challenging because of intra- and inter-tumor heterogeneity. Interestingly, naturally derived bioactive compounds have unique ability to modulate wide-ranging deregulated oncogenic cell signaling pathways. In this review, we have focused on the available evidence related to regulation of PI3K/AKT/mTOR, Wnt/β-catenin, NF-κB and TRAIL/TRAIL-R by fisetin in different cancers. Fisetin has also been shown to inhibit the metastatic spread of cancer cells in tumor-bearing mice. We have also summarized how fisetin regulated autophagy in different cancers. In addition, this review also covers fisetin-mediated regulation of VEGF/VEGFR, EGFR, necroptosis and Hippo pathway. Fisetin has entered into clinical trials particularly in context of COVID19-associated inflammations. Furthermore, fisetin mediated effects are also being tested in clinical trials with reference to osteoarthritis and senescence. These developments will surely pave the way for full-fledge and well-designed clinical trials of fisetin in different cancers. However, we still have to comprehensively analyze and fully unlock pharmacological potential of fisetin against different oncogenic signaling cascades and non-coding RNAs. Fisetin has remarkable potential as chemopreventive agent and future studies must converge on the identification of additional regulatory roles of fisetin for inhibition and prevention of cancers.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Chemoprevention
Humans
Intercellular Signaling Peptides and Proteins metabolism
NF-kappa B metabolism
Neoplasms metabolism
Neoplasms prevention & control
Receptors, Vascular Endothelial Growth Factor metabolism
Signal Transduction drug effects
TOR Serine-Threonine Kinases metabolism
beta Catenin metabolism
Antineoplastic Agents, Phytogenic administration & dosage
Flavonols administration & dosage
Nanostructures administration & dosage
Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1096-1186
- Volume :
- 172
- Database :
- MEDLINE
- Journal :
- Pharmacological research
- Publication Type :
- Academic Journal
- Accession number :
- 34302980
- Full Text :
- https://doi.org/10.1016/j.phrs.2021.105784