Ecdysteroids from the Aerial Parts of Paris verticillata.

Authors :: Jiang P
Liu Y
Sun YP
Pan J
Guan W
Xu ZP
Li XM
Wang SY
Mei Y
Kuang HX
Yang BY
Source :: Chemistry & biodiversity [Chem Biodivers] 2021 Sep; Vol. 18 (9), pp. e2100239. Date of Electronic Publication: 2021 Aug 09.
Publication Year :: 2021
Abstract: Two new ecdysteroids 14-epi-polypodine B (1) and 22-oxo-hydroxyecdysterone (2), along with nine known compounds, polypodine B (3), viticosterone E (4), 20-hdroxyecdysone-2-acetate (5), 22-oxo-20-hydroxyecdysone (6), 5-hydroxyecdysone (7), pinnatasterone (8), 3-epi-20-hydroxyecdysone (9), ecdysterone (10) and stachysterone B (11), were isolated from the aerial parts of Paris verticillata. The structures of all compounds were elucidated by extensive spectroscopic analysis, quantum chemical calculations and ANN-PRA/DP4 <superscript>+</superscript> probability analysis. Among them, the absolute configuration of compound 1 and 2 was unambiguous determined by ECD. Also, the isolated compounds were assessed for their cytotoxic activities. Compounds 2, 3 and 7 exhibited significant cytotoxic activities against PC12, LN299 and SMCC7721 cells.<br /> (© 2021 Wiley-VHCA AG, Zurich, Switzerland.)