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The Potential Impact of High-Risk Human Papillomavirus-Negative Cervical Intraepithelial Neoplasia 2+ on Primary Human Papillomavirus Screening.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2022 Jan 06; Vol. 157 (1), pp. 130-135. - Publication Year :
- 2022
-
Abstract
- Objectives: To investigate the prevalence of high-risk human papillomavirus (HPV)-negative cervical intraepithelial neoplasia (CIN) and invasive cervical carcinoma (ICC) and to analyze the distribution of other genotypes in this subset.<br />Methods: In total, 431 women who underwent excisional surgical treatment for CIN or ICC at the European Institute of Oncology, Milan, Italy, from January 2016 to December 2017 were retrospectively analyzed. The Linear Array HPV genotyping test (Roche Diagnostics) was performed on a postaliquot from high-risk-HPV-negative liquid-based cervical specimens, when available. Patient characteristics and the prevalence of high-risk-HPV-negative CIN grade 2 or worse (CIN2+) were tabulated. We used t tests to compare age between high-risk-HPV-positive and high-risk-HPV-negative patients.<br />Results: Overall, 8.9% of CIN2+ and 7.5% of ICC cases were high-risk HPV negative. There was no age difference between high-risk-HPV-negative CIN2+ women (mean [SD], 41.3 [8.7] years) and high-risk-HPV-positive women (mean [SD], 39.5 [9.0] years) (P = .28). The Linear Array result was available in 22 cases. Most high-risk-HPV-negative patients were positive for a single other genotype infection (32.6%). HPV 73 was the most prevalent genotype, followed by HPV 53 and HPV 84. HPV 26 was detected in 1 case of ICC.<br />Conclusions: Our results showed a not-negligible proportion of high-risk-HPV-negative CIN2+, suggesting that cotesting would not miss these cases.<br /> (© American Society for Clinical Pathology, 2021. All rights reserved.For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Child, Preschool
Female
Genotype
Humans
Papillomaviridae genetics
Retrospective Studies
Alphapapillomavirus
Papillomavirus Infections diagnosis
Papillomavirus Infections epidemiology
Uterine Cervical Neoplasms diagnosis
Uterine Cervical Neoplasms epidemiology
Uterine Cervical Dysplasia diagnosis
Uterine Cervical Dysplasia epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1943-7722
- Volume :
- 157
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 34302334
- Full Text :
- https://doi.org/10.1093/ajcp/aqab103