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Rapidly progressive HBsAg-positive hepatitis in Italy. The role of hepatitis delta virus infection.
- Source :
-
Journal of hepatology [J Hepatol] 1987 Dec; Vol. 5 (3), pp. 274-81. - Publication Year :
- 1987
-
Abstract
- Serum or liver markers of hepatitis delta virus (HDV) infection were found in 20 of 22 (90%) Italian patients presenting with an ostensible type B hepatitis that ran an accelerated course to cirrhosis. The features of the illness conformed to a syndrome of HDV infection in young males carrying the hepatitis B surface antigen (HBsAg); a latent HBsAg state was documented in many patients by a history of prior exposure to the hepatitis B virus (HBV) or by the absence of IgM antibodies to the HB core antigen. Characteristic of the disease were the clinical overture as a severe hepatitis, the lobular involvement by an extensive necroinflammatory reaction, the exuberant expression of intrahepatic hepatitis delta antigen and an atypical HBV profile of inactive infection or accelerated seroconversion from HBeAg to anti-HBe. Superimposed upon HBV infection, HDV may create a rapidly progressive course which resembles very aggressive hepatitis B but is infrequently observed in hepatitis B alone.
- Subjects :
- Adolescent
Adult
Hepatitis B complications
Hepatitis B Core Antigens immunology
Hepatitis D complications
Humans
Italy
Liver immunology
Liver pathology
Liver Cirrhosis complications
Liver Cirrhosis immunology
Liver Cirrhosis pathology
Longitudinal Studies
Male
Time Factors
Hepatitis B immunology
Hepatitis B Surface Antigens analysis
Hepatitis D immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0168-8278
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 3429834
- Full Text :
- https://doi.org/10.1016/s0168-8278(87)80032-6