Back to Search
Start Over
Cyclic nucleotide signaling and pacemaker activity.
- Source :
-
Progress in biophysics and molecular biology [Prog Biophys Mol Biol] 2021 Nov; Vol. 166, pp. 29-38. Date of Electronic Publication: 2021 Jul 20. - Publication Year :
- 2021
-
Abstract
- The sinoatrial node (SAN) is the natural pacemaker of the heart, producing the electrical impulse that initiates every heart beat. Its activity is tightly controlled by the autonomic nervous system, and by circulating and locally released factors. Neurohumoral regulation of heart rate plays a crucial role in the integration of vital functions and influences behavior and ability to respond to changing environmental conditions. At the cellular level, modulation of SAN activity occurs through intracellular signaling pathways involving cyclic nucleotides: cyclic AMP (cAMP) and cyclic GMP (cGMP). In this Review, dedicated to Professor Dario DiFrancesco and his accomplishements in the field of cardiac pacemaking, we summarize all findings on the role of cyclic nucleotides signaling in regulating the key actors of cardiac automatism, and we provide an up-to-date review on cAMP- and cGMP-phosphodiesterases (PDEs), compellingly involved in this modulation.<br />Competing Interests: Declaration of competing interest The Authors declare no conflicts of interest.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Subjects :
- Cyclic AMP
Signal Transduction
Sinoatrial Node
Cyclic GMP
Nucleotides, Cyclic
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1732
- Volume :
- 166
- Database :
- MEDLINE
- Journal :
- Progress in biophysics and molecular biology
- Publication Type :
- Academic Journal
- Accession number :
- 34298001
- Full Text :
- https://doi.org/10.1016/j.pbiomolbio.2021.07.007