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Role of Bacterial Infection in the Development of Acute Liver Failure in Patients with Decompensated Alcoholic Liver Cirrhosis.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2021 Jul; Vol. 171 (3), pp. 322-326. Date of Electronic Publication: 2021 Jul 23. - Publication Year :
- 2021
-
Abstract
- We examined 74 patients with acute decompensation of alcoholic liver cirrhosis: 34 (45.9%) with bacterial infection (group 1) and 40 (54.1%) without bacterial infection (group 2). The degree and index of acute-on-chronic liver failure (ACLF) were determined using an on-line CLIF-C ACLF Calculator and the levels of cytokeratin-18 fragments, TNFα, IL-1β, IL-4, IL-6, and IL-8. In group 1, AST, cytokeratin-18, TNFα, IL-1β, IL-6, degree and score of ACLF were significantly higher than in group 2. ACLF developed in 18 (52.9%) patients in group 1 and in 11 (27.5%) (p<0.05) patients in group 2. Within 1 month, 10 (29.4%) patients of group 1 and 2 (5%) patients of group 2 died (p<0.05). Patients with bacterial infection showed a more severe course of alcoholic liver cirrhosis and ACLF than those without bacterial infection.<br /> (© 2021. Springer Science+Business Media, LLC, part of Springer Nature.)
- Subjects :
- Acute-On-Chronic Liver Failure blood
Acute-On-Chronic Liver Failure mortality
Acute-On-Chronic Liver Failure pathology
Adult
Aspartate Aminotransferases blood
Bacterial Infections blood
Bacterial Infections mortality
Bacterial Infections pathology
Biomarkers blood
Case-Control Studies
Female
Humans
Interleukin-1beta blood
Interleukin-4 blood
Interleukin-6 blood
Interleukin-8 blood
Keratin-18 blood
Liver metabolism
Liver pathology
Liver Cirrhosis, Alcoholic blood
Liver Cirrhosis, Alcoholic mortality
Liver Cirrhosis, Alcoholic pathology
Male
Middle Aged
Prognosis
Severity of Illness Index
Survival Analysis
Tumor Necrosis Factor-alpha blood
Acute-On-Chronic Liver Failure microbiology
Bacterial Infections microbiology
Liver Cirrhosis, Alcoholic microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-8221
- Volume :
- 171
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34297284
- Full Text :
- https://doi.org/10.1007/s10517-021-05220-5