SARS-CoV-2 Neutralization Resistance Mutations in Patient with HIV/AIDS, California, USA.

Authors :: Hoffman SA
Costales C
Sahoo MK
Palanisamy S
Yamamoto F
Huang C
Verghese M
Solis DA
Sibai M
Subramanian A
Tompkins LS
Grant P
Shafer RW
Pinsky BA
Source :: Emerging infectious diseases [Emerg Infect Dis] 2021; Vol. 27 (10), pp. 2720-2723. Date of Electronic Publication: 2021 Jul 23.
Publication Year :: 2021
Abstract: We report persistent severe acute respiratory syndrome coronavirus 2 infection in a patient with HIV/AIDS; the virus developed spike N terminal domain and receptor binding domain neutralization resistance mutations. Our findings suggest that immunocompromised patients can harbor emerging variants of severe acute respiratory syndrome coronavirus 2.

Subjects :: Humans
Mutation
Protein Binding
SARS-CoV-2
Spike Glycoprotein, Coronavirus genetics
Acquired Immunodeficiency Syndrome
COVID-19

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