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Glycyrrhetinic acid: a promising scaffold for the discovery of anticancer agents.

Authors :
Hussain H
Ali I
Wang D
Hakkim FL
Westermann B
Ahmed I
Ashour AM
Khan A
Hussain A
Green IR
Shah STA
Source :
Expert opinion on drug discovery [Expert Opin Drug Discov] 2021 Dec; Vol. 16 (12), pp. 1497-1516. Date of Electronic Publication: 2021 Jul 30.
Publication Year :
2021

Abstract

Introduction: Oleanane-type pentacyclic triterpenes named glycyrrhetinic acids (GAs) featuring a C-30 carboxylic acid group, are extracted from the licorice ( Glycyrrhiza uralensis ). Numerous biological properties of GA have been reported and have attracted researchers from all over the world in recent years due to the peculiar GA scaffold-based semisynthetic cytotoxic effects.<br />Areas Covered: This review represents the applications of semisynthetic derivatives of GA for the development of future cancer treatments. Included in the review are important structural features of the semisynthetic GAs crucial for cytotoxic effects.<br />Expert Opinion: Numerous semisynthetic GA derivatives illustrated excellent cytotoxic effects toward various cancer cells. Notably the C- <subscript>3</subscript> (OH) at ring A along with C <subscript>30-</subscript> CO <subscript>2</subscript> H at ring E as vital structural features, make GA very appealing as a lead scaffold for medicinal chemistry, since these two groups permit the creation of further chemical diversity geared toward improved cytotoxic effects. Furthermore, numerous GA derivatives have been synthesized and indicate that compounds featuring cyanoenone moieties in ring A, or compounds having the amino group or nitrogen comprising heterocycles and hybrids thereof, illustrate more potent cytotoxicity. Furthermore, GA has a great capability to be conjugated with other anticancer molecules to synergistically enhance their combined cytotoxicity.

Details

Language :
English
ISSN :
1746-045X
Volume :
16
Issue :
12
Database :
MEDLINE
Journal :
Expert opinion on drug discovery
Publication Type :
Academic Journal
Accession number :
34294017
Full Text :
https://doi.org/10.1080/17460441.2021.1956901