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The PROTACtable genome.
- Source :
-
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2021 Oct; Vol. 20 (10), pp. 789-797. Date of Electronic Publication: 2021 Jul 20. - Publication Year :
- 2021
-
Abstract
- Proteolysis-targeting chimeras (PROTACs) are an emerging drug modality that may offer new opportunities to circumvent some of the limitations associated with traditional small-molecule therapeutics. By analogy with the concept of the 'druggable genome', the question arises as to which potential drug targets might PROTAC-mediated protein degradation be most applicable. Here, we present a systematic approach to the assessment of the PROTAC tractability (PROTACtability) of protein targets using a series of criteria based on data and information from a diverse range of relevant publicly available resources. Our approach could support decision-making on whether or not a particular target may be amenable to modulation using a PROTAC. Using our approach, we identified 1,067 proteins of the human proteome that have not yet been described in the literature as PROTAC targets that offer potential opportunities for future PROTAC-based efforts.<br /> (© 2021. Springer Nature Limited.)
- Subjects :
- Animals
Humans
Research Design
Small Molecule Libraries
Genome
Drug Design
Subjects
Details
- Language :
- English
- ISSN :
- 1474-1784
- Volume :
- 20
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nature reviews. Drug discovery
- Publication Type :
- Academic Journal
- Accession number :
- 34285415
- Full Text :
- https://doi.org/10.1038/s41573-021-00245-x