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Health-related quality of life in amyotrophic lateral sclerosis using EQ-5D-5L.
- Source :
-
Health and quality of life outcomes [Health Qual Life Outcomes] 2021 Jul 20; Vol. 19 (1), pp. 181. Date of Electronic Publication: 2021 Jul 20. - Publication Year :
- 2021
-
Abstract
- Background: The study aimed to appraise the health-related quality of life (HRQoL) measured by the five-level EuroQol-5 dimensions (EQ-5D-5L) in amyotrophic lateral sclerosis (ALS), and to explore the associations between non-motor symptoms (mood changes, cognitive disturbances and sleep disturbances).<br />Methods: EQ-5D-5L descriptive scores were converted into a single aggregated "health utility" score. A calibrated visual analog scale (EQ-VAS) was used for self-rating of current health status. Multiple logistic regression analysis was used to explore the factors associated with HRQoL.<br />Results: Among the 547 enrolled ALS patients who were assessed using EQ-5D-5L, the highest frequency of reported problems was with usual activities (76.7%), followed by self-care (68.8%) and anxiety/depression (62.0%). The median health utility score was 0.78 and the median EQ-VAS score was 70. Clinical factors corresponding to differences in the EQ-5D-5L health utility score included age of onset, onset region, the ALS Functional Rating Scale-Revised (ALSFRS-R) score, and King's College stages. Patients with depression, anxiety, and poor sleep had lower health utility scores. Patients with excessive daytime sleepiness and rapid eye movement sleep behavior disorder had lower EQ-VAS scores. Multivariate logistic analysis indicated that ALSFRS-R scores, depression, and anxiety were associated with health utility scores. After adjusting other parameters, ALSFRS-R score, stages, and depression were significantly associated with EQ-VAS scores (Pā<ā0.05).<br />Conclusion: This study examined HRQoL in ALS patients using the Chinese version of the EQ-5D-5L scale across different stages of the disease. We found that HRQoL is related to disease severity and to mood disturbances. Management of non-motor symptoms may help improve HRQoL in ALS patients.<br /> (© 2021. The Author(s).)
- Subjects :
- Activities of Daily Living
Adult
Aged
Amyotrophic Lateral Sclerosis psychology
Anxiety
Cognitive Dysfunction
Depression
Female
Health Status
Humans
Male
Middle Aged
Multivariate Analysis
Pain Measurement
Self Care
Severity of Illness Index
Surveys and Questionnaires
Visual Analog Scale
Amyotrophic Lateral Sclerosis diagnosis
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 1477-7525
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Health and quality of life outcomes
- Publication Type :
- Academic Journal
- Accession number :
- 34284776
- Full Text :
- https://doi.org/10.1186/s12955-021-01822-9