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Neurovascular protection of salvianolic acid B and ginsenoside Rg1 combination against acute ischemic stroke in rats.
- Source :
-
Neuroreport [Neuroreport] 2021 Sep 08; Vol. 32 (13), pp. 1140-1146. - Publication Year :
- 2021
-
Abstract
- Ischemic stroke continues to be a major global health problem associated with considerable mortality and morbidity. Thus, it is still targeted by researchers for developing new strategies or drugs to alleviate the lesion of stroke. In the present study, both the permanent occlusion of the middle cerebral artery (MCAO) model and the restoration of cerebral blood flow after middle cerebral artery occlusion (CI/R) model were set up for evaluating the efficiency of salvianolic acid B and ginsenoside Rg1 combination (SalB-Rg1). SalB-Rg1 decreased infarct area through 3,5-triphenyltetrazolium chloride stain and improved neurological behavior through Longa Score or Left-Biased Swings on both MCAO rats and CI/R rats. Neural protection of SalB-Rg1 against ischemia or ischemic reperfusion injury was evidenced by the inhibition of nucleus pyknosis, liquefaction necrosis through H&E stain and Nissl stain. Furthermore, protection of SalB-Rg1 on blood-brain barrier (BBB) was more significant on CI/R rats, accompanying with the downregulation of matrix metalloproteinase-2 and matrix metalloproteinase-9, and recovery of zonula occludens-1 expression. These results provide compelling evidence that SalB-Rg1 holds the potential to be developed as an optimal therapeutic strategy to alleviate the injury of ischemia or ischemic reperfusion.<br /> (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
- Subjects :
- Alkenes pharmacology
Animals
Blood-Brain Barrier drug effects
Blood-Brain Barrier pathology
Brain pathology
Ginsenosides pharmacology
Ischemic Stroke pathology
Male
Neuroprotective Agents pharmacology
Polyphenols pharmacology
Rats
Rats, Sprague-Dawley
Alkenes therapeutic use
Brain drug effects
Ginsenosides therapeutic use
Ischemic Stroke drug therapy
Neuroprotective Agents therapeutic use
Polyphenols therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1473-558X
- Volume :
- 32
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Neuroreport
- Publication Type :
- Academic Journal
- Accession number :
- 34284451
- Full Text :
- https://doi.org/10.1097/WNR.0000000000001706