Back to Search
Start Over
Kinetics of the Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and Serological Estimation of Time Since Infection.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2021 Nov 16; Vol. 224 (9), pp. 1489-1499. - Publication Year :
- 2021
-
Abstract
- Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a complex antibody response that varies by orders of magnitude between individuals and over time.<br />Methods: We developed a multiplex serological test for measuring antibodies to 5 SARS-CoV-2 antigens and the spike proteins of seasonal coronaviruses. We measured antibody responses in cohorts of hospitalized patients and healthcare workers followed for up to 11 months after symptoms. A mathematical model of antibody kinetics was used to quantify the duration of antibody responses. Antibody response data were used to train algorithms for estimating time since infection.<br />Results: One year after symptoms, we estimate that 36% (95% range, 11%-94%) of anti-Spike immunoglobulin G (IgG) remains, 31% (95% range, 9%-89%) anti-RBD IgG remains, and 7% (1%-31%) of anti-nucleocapsid IgG remains. The multiplex assay classified previous infections into time intervals of 0-3 months, 3-6 months, and 6-12 months. This method was validated using data from a seroprevalence survey in France, demonstrating that historical SARS-CoV-2 transmission can be reconstructed using samples from a single survey.<br />Conclusions: In addition to diagnosing previous SARS-CoV-2 infection, multiplex serological assays can estimate the time since infection, which can be used to reconstruct past epidemics.<br /> (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Antibody Formation
Antibody Specificity
COVID-19 epidemiology
Female
France epidemiology
Humans
Immunoglobulin G blood
Kinetics
Male
Middle Aged
SARS-CoV-2 immunology
Sensitivity and Specificity
Seroepidemiologic Studies
Young Adult
Antibodies, Viral blood
COVID-19 blood
COVID-19 immunology
Serologic Tests methods
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 224
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 34282461
- Full Text :
- https://doi.org/10.1093/infdis/jiab375