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Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability.
- Source :
-
Scientific reports [Sci Rep] 2021 Jul 19; Vol. 11 (1), pp. 14675. Date of Electronic Publication: 2021 Jul 19. - Publication Year :
- 2021
-
Abstract
- In this study, the intestinal permeability of metal(loid)s (MLs) such as arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) was examined, as influenced by gut microbes and chelating agents using an in vitro gastrointestinal/Caco-2 cell intestinal epithelium model. The results showed that in the presence of gut microbes or chelating agents, there was a significant decrease in the permeability of MLs (As-7.5%, Cd-6.3%, Pb-7.9% and Hg-8.2%) as measured by apparent permeability coefficient value (P <subscript>app</subscript> ), with differences in ML retention and complexation amongst the chelants and the gut microbes. The decrease in ML permeability varied amongst the MLs. Chelating agents reduce intestinal absorption of MLs by forming complexes thereby making them less permeable. In the case of gut bacteria, the decrease in the intestinal permeability of MLs may be associated to a direct protection of the intestinal barrier against the MLs or indirect intestinal ML sequestration by the gut bacteria through adsorption on bacterial surface. Thus, both gut microbes and chelating agents can be used to decrease the intestinal permeability of MLs, thereby mitigating their toxicity.<br /> (© 2021. The Author(s).)
- Subjects :
- Biological Availability
Biological Transport
Caco-2 Cells
Cadmium pharmacokinetics
Gastrointestinal Tract metabolism
Humans
Intestinal Mucosa metabolism
Lead pharmacokinetics
Mercury pharmacokinetics
Permeability
Arsenic pharmacokinetics
Intestinal Absorption physiology
Metals, Heavy pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 34282255
- Full Text :
- https://doi.org/10.1038/s41598-021-94174-9