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Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery.
- Source :
-
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia [Ann Thorac Cardiovasc Surg] 2022 Dec 20; Vol. 28 (6), pp. 448-452. Date of Electronic Publication: 2021 Jul 16. - Publication Year :
- 2022
-
Abstract
- Introduction: Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder. Paraneoplastic SPS associated with malignant tumors such as thymoma occurs in approximately 5% of all SPS cases. We present a rare case of thymoma accompanied by SPS successfully treated using surgery.<br />Presentation of Case: A 26-year-old woman presented with lower limbs convulsions and gait disturbance and complained of leg pain. Cerebrospinal fluid and blood test results showed a high level of anti-glutamic acid decarboxylase (GAD) antibodies. Computed tomography showed anterior mediastinal tumor suggestive of a thymoma. She underwent extended thymectomy, and her symptoms gradually improved after surgery. No evidence of recurrent thymoma and SPS has been observed over 44 months.<br />Conclusion: Surgical treatment would be effective for patients with SPS and thymoma.
- Subjects :
- Humans
Female
Adult
Treatment Outcome
Neoplasm Recurrence, Local complications
Thymoma complications
Thymoma diagnostic imaging
Thymoma surgery
Stiff-Person Syndrome diagnosis
Stiff-Person Syndrome diagnostic imaging
Thymus Neoplasms complications
Thymus Neoplasms diagnostic imaging
Thymus Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 2186-1005
- Volume :
- 28
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
- Publication Type :
- Academic Journal
- Accession number :
- 34275989
- Full Text :
- https://doi.org/10.5761/atcs.cr.21-00052