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A model for quantitative evaluation of embolic stroke therapy.
- Source :
-
Brain research [Brain Res] 1987 Dec 01; Vol. 435 (1-2), pp. 305-9. - Publication Year :
- 1987
-
Abstract
- We developed a small animal embolic stroke model for pharmacological screening trials. Microspheres are injected into the carotid circulations and group embolus dose-response relationships are calculated. Emboli quantity is related to neurologic injury, and small changes in neurologic function are detectable. Rabbits tolerated twice as many microspheres when cyproheptadine-treated after embolization. This demonstrated both the sensitivity of the model and the value of serotonin antagonists in reducing neurological injury.
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 435
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 3427458
- Full Text :
- https://doi.org/10.1016/0006-8993(87)91613-1