Prostaglandin I 2 and T Regulatory Cell Function: Broader Impacts.

Authors :: Norlander AE
Peebles RS
Source :: DNA and cell biology [DNA Cell Biol] 2021 Oct; Vol. 40 (10), pp. 1231-1234. Date of Electronic Publication: 2021 Jul 15.
Publication Year :: 2021
Abstract: Tregulatory cells (Tregs) are an important member of the adaptive immune system and function to reduce and resolve inflammation. Prostaglandin I <subscript>2</subscript> (PGI <subscript>2</subscript> ) is a lipid mediator that has potent anti-inflammatory effects on immune cells. Several studies have investigated the interplay between PGI <subscript>2</subscript> and Tregs. Together, the data from these studies demonstrate that PGI <subscript>2</subscript> promotes the formation and function of Tregs. This suggests that therapeutic supplementation of PGI <subscript>2</subscript> may be a treatment for various autoimmune or inflammatory diseases through enhancement of Treg function.