Epigenetic Reprogramming of CD4 + Helper T Cells as a Strategy to Improve Anticancer Immunotherapy.

Evidences highlight the role of various CD4 ⁺ helper T cells (CD4 ⁺ Th) subpopulations in orchestrating the immune responses against cancers. Epigenetics takes an important part in the regulation of CD4 ⁺ Th polarization and plasticity. In this review, we described the epigenetic factors that govern CD4 ⁺ T cells differentiation and recruitment in the tumor microenvironment and their subsequent involvement in the antitumor immunity. Finally, we discussed how to manipulate tumor reactive CD4 ⁺ Th responses by epigenetic drugs to improve anticancer immunotherapy.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Renaude, Kroemer, Borg, Peixoto, Hervouet, Loyon and Adotévi.)