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Molecular networks of the FOXP2 transcription factor in the brain.
- Source :
-
EMBO reports [EMBO Rep] 2021 Aug 04; Vol. 22 (8), pp. e52803. Date of Electronic Publication: 2021 Jul 14. - Publication Year :
- 2021
-
Abstract
- The discovery of the FOXP2 transcription factor, and its implication in a rare severe human speech and language disorder, has led to two decades of empirical studies focused on uncovering its roles in the brain using a range of in vitro and in vivo methods. Here, we discuss what we have learned about the regulation of FOXP2, its downstream effectors, and its modes of action as a transcription factor in brain development and function, providing an integrated overview of what is currently known about the critical molecular networks.<br /> (© 2021 The Authors. Published under the terms of the CC BY 4.0 license.)
Details
- Language :
- English
- ISSN :
- 1469-3178
- Volume :
- 22
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- EMBO reports
- Publication Type :
- Academic Journal
- Accession number :
- 34260143
- Full Text :
- https://doi.org/10.15252/embr.202152803