Consensus molecular subtypes of primary colon tumors and their hepatic metastases.

Aim: This pilot study aimed to evaluate the congruency in consensus molecular subtypes (CMS) of primary colorectal cancer and corresponding hepatic metastasis (HM).
Materials & Methods: RNA was extracted from both primary colorectal cancer and HM from ten patients, sequenced to establish gene-expression profiles and classified into CMS. Clinical data were collected retrospectively.
Results: Of the ten patients recruited, nine had primary tumors that were classifiable: seven were CMS2, one was CMS3 and one was CMS4. Five had incongruent classification in the corresponding HM. Three out of the five patients with incongruent classification had received adjuvant chemotherapy prior to hepatic resection.
Conclusion: A change in CMS type between matched primary and metastatic colorectal tumors is common and may be attributable to chemotherapy.
Competing Interests: Financial & competing interests disclosure YC Lau: Richard Stewart Scholarship from the University of Otago; R Purcell: Maurice and Phyllis Paykel Trust; Gut Cancer Foundation (NZ), with support from the Hugh Green Foundation; Colorectal Surgical Society of Australia and New Zealand (CSSANZ); The Health Research Council of New Zealand. The funding bodies had no role in the design of the study or collection, analysis and interpretation of data or in writing the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
(© 2021 The Authors.)