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The role of PD-L1 in the immune dysfunction that mediates hypoxia-induced multiple organ injury.
- Source :
-
Cell communication and signaling : CCS [Cell Commun Signal] 2021 Jul 13; Vol. 19 (1), pp. 76. Date of Electronic Publication: 2021 Jul 13. - Publication Year :
- 2021
-
Abstract
- Hypoxia is a pathological condition common to many diseases, although multiple organ injuries induced by hypoxia are often overlooked. There is increasing evidence to suggest that the hypoxic environment may activate innate immune cells and suppress adaptive immunity, further stimulating inflammation and inhibiting immunosurveillance. We found that dysfunctional immune regulation may aggravate hypoxia-induced tissue damage and contribute to secondary injury. Among the diverse mechanisms of hypoxia-induced immune dysfunction identified to date, the role of programmed death-ligand 1 (PD-L1) has recently attracted much attention. Besides leading to tumour immune evasion, PD-L1 has also been found to participate in the progression of the immune dysfunction which mediates hypoxia-induced multiple organ injury. In this review, we aimed to summarise the role of immune dysfunction in hypoxia-induced multiple organ injury, the effects of hypoxia on the cellular expression of PD-L1, and the effects of upregulated PD-L1 expression on immune regulation. Furthermore, we summarise the latest information pertaining to the involvement, diagnostic value, and therapeutic potential of immunosuppression induced by PD-L1 in various types of hypoxia-related diseases, including cancers, ischemic stroke, acute kidney injury, and obstructive sleep apnoea. Video Abstract.<br /> (© 2021. The Author(s).)
- Subjects :
- Acute Kidney Injury genetics
Acute Kidney Injury immunology
Adaptive Immunity immunology
B7-H1 Antigen genetics
Humans
Immunity, Innate genetics
Inflammation genetics
Ischemic Stroke genetics
Ischemic Stroke immunology
Monitoring, Immunologic
Neoplasms genetics
Neoplasms immunology
Sleep Apnea, Obstructive genetics
Sleep Apnea, Obstructive immunology
Tumor Hypoxia immunology
Adaptive Immunity genetics
B7-H1 Antigen immunology
Inflammation immunology
Tumor Hypoxia genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1478-811X
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cell communication and signaling : CCS
- Publication Type :
- Academic Journal
- Accession number :
- 34256773
- Full Text :
- https://doi.org/10.1186/s12964-021-00742-x