Benchmark Acetylene Binding Affinity and Separation through Induced Fit in a Flexible Hybrid Ultramicroporous Material.

Structural changes at the active site of an enzyme induced by binding to a substrate molecule can result in enhanced activity in biological systems. Herein, we report that the new hybrid ultramicroporous material sql-SIFSIX-bpe-Zn exhibits an induced fit binding mechanism when exposed to acetylene, C ₂ H ₂ . The resulting phase change affords exceptionally strong C ₂ H ₂ binding that in turn enables highly selective C ₂ H ₂ /C ₂ H ₄ and C ₂ H ₂ /CO ₂ separation demonstrated by dynamic breakthrough experiments. sql-SIFSIX-bpe-Zn was observed to exhibit at least four phases: as-synthesised (α); activated (β); and C ₂ H ₂ induced phases (β' and γ). sql-SIFSIX-bpe-Zn-β exhibited strong affinity for C ₂ H ₂ at ambient conditions as demonstrated by benchmark isosteric heat of adsorption (Q _st ) of 67.5 kJ mol ^-1 validated through in situ pressure gradient differential scanning calorimetry (PG-DSC). Further, in situ characterisation and DFT calculations provide insight into the mechanism of the C ₂ H ₂ induced fit transformation, binding positions and the nature of host-guest and guest-guest interactions.
(© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)