Back to Search Start Over

Association between high mobility group box 1 protein and juvenile idiopathic arthritis: a prospective longitudinal study.

Authors :
Xu D
Zhang Y
Zhang ZY
Tang XM
Source :
Pediatric rheumatology online journal [Pediatr Rheumatol Online J] 2021 Jul 12; Vol. 19 (1), pp. 112. Date of Electronic Publication: 2021 Jul 12.
Publication Year :
2021

Abstract

Objective: To analyze the levels of high mobility group box 1 (HMGB1) protein on different courses of juvenile idiopathic arthritis (JIA).<br />Methods: In our prospective longitudinal study, children with JIA were included with their blood samples collected at the first visit, 1-month, 3-month, and 6-month follow-up, respectively. Samples were also collected from healthy controls and children with reactive arthritis at the first visit. Levels of HMGB1 were determined using enzyme-linked immunosorbent assays. Clinical disease characteristics and routine laboratory findings were analyzed as well.<br />Results: A total of 64 children were enrolled, of whom 31 (48.4%) were female. The median age at the first visit for participants with JIA was 9.25 years (range, 1.42-15.42) and the median duration of disease was 2.38 months (range, 1.53-49.31). Serum HMGB1 levels at the first visit were significantly elevated in children with systemic JIA compared with other groups, and so were in enthesitis-related arthritis versus healthy controls. Significant correlations were established at the first visit between HMGB1 levels and duration of disease, C-reactive protein, percentage of neutrophils, and ferritin. Data from all samples revealed that serum HMGB1 levels in JIA were significantly associated with erythrocyte sedimentation rates, C-reactive protein, percentage of neutrophils, and disease activity scores.<br />Conclusions: Serum HMGB1 may be associated with clinical disease activity of JIA and specifically increased at the first visit in children with systemic JIA, suggesting its function as a sensitive inflammatory marker. Further large-scale studies are warranted to explore its spectrum in JIA.<br /> (© 2021. The Author(s).)

Details

Language :
English
ISSN :
1546-0096
Volume :
19
Issue :
1
Database :
MEDLINE
Journal :
Pediatric rheumatology online journal
Publication Type :
Academic Journal
Accession number :
34247641
Full Text :
https://doi.org/10.1186/s12969-021-00587-1