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Gut microbiome heritability is nearly universal but environmentally contingent.
Gut microbiome heritability is nearly universal but environmentally contingent.
- Source :
-
Science (New York, N.Y.) [Science] 2021 Jul 09; Vol. 373 (6551), pp. 181-186. - Publication Year :
- 2021
-
Abstract
- Relatives have more similar gut microbiomes than nonrelatives, but the degree to which this similarity results from shared genotypes versus shared environments has been controversial. Here, we leveraged 16,234 gut microbiome profiles, collected over 14 years from 585 wild baboons, to reveal that host genetic effects on the gut microbiome are nearly universal. Controlling for diet, age, and socioecological variation, 97% of microbiome phenotypes were significantly heritable, including several reported as heritable in humans. Heritability was typically low (mean = 0.068) but was systematically greater in the dry season, with low diet diversity, and in older hosts. We show that longitudinal profiles and large sample sizes are crucial to quantifying microbiome heritability, and indicate scope for selection on microbiome characteristics as a host phenotype.<br /> (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
- Subjects :
- Actinobacteria classification
Actinobacteria genetics
Actinobacteria growth & development
Actinobacteria isolation & purification
Aging
Animals
Bacteria genetics
Bacteria growth & development
Bacteria isolation & purification
Bacteroidetes classification
Bacteroidetes genetics
Bacteroidetes growth & development
Bacteroidetes isolation & purification
Diet
Feces microbiology
Female
Firmicutes classification
Firmicutes genetics
Firmicutes growth & development
Firmicutes isolation & purification
Genotype
Humans
Male
Papio genetics
Phenotype
Seasons
Social Behavior
Bacteria classification
Environment
Gastrointestinal Microbiome genetics
Papio microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 373
- Issue :
- 6551
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 34244407
- Full Text :
- https://doi.org/10.1126/science.aba5483