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Association of the CXCL9-CXCR3 and CXCL13-CXCR5 axes with B-cell trafficking in giant cell arteritis and polymyalgia rheumatica.
- Source :
-
Journal of autoimmunity [J Autoimmun] 2021 Sep; Vol. 123, pp. 102684. Date of Electronic Publication: 2021 Jul 06. - Publication Year :
- 2021
-
Abstract
- Objective: B-cells are present in the inflamed arteries of giant cell arteritis (GCA) patients and a disturbed B-cell homeostasis is reported in peripheral blood of both GCA and the overlapping disease polymyalgia rheumatica (PMR). In this study, we aimed to investigate chemokine-chemokine receptor axes governing the migration of B-cells in GCA and PMR.<br />Methods: We performed Luminex screening assay for serum levels of B-cell related chemokines in treatment-naïve GCA (n = 41), PMR (n = 31) and age- and sex matched healthy controls (HC, n = 34). Expression of chemokine receptors on circulating B-cell subsets were investigated by flow cytometry. Immunohistochemistry was performed on GCA temporal artery (n = 14) and aorta (n = 10) and on atherosclerosis aorta (n = 10) tissue.<br />Results: The chemokines CXCL9 and CXCL13 were significantly increased in the circulation of treatment-naïve GCA and PMR patients. CXCL13 increased even further after three months of glucocorticoid treatment. At baseline CXCL13 correlated with disease activity markers. Peripheral CXCR3+ and CXCR5+ switched memory B-cells were significantly reduced in both patient groups and correlated inversely with their complementary chemokines CXCL9 and CXCL13. At the arterial lesions in GCA, CXCR3+ and CXCR5+ B-cells were observed in areas with high CXCL9 and CXCL13 expression.<br />Conclusion: Changes in systemic and local chemokine and chemokine receptor pathways related to B-cell migration were observed in GCA and PMR mainly in the CXCL9-CXCR3 and CXCL13-CXCR5 axes. These changes can contribute to homing and organization of B-cells in the vessel wall and provide further evidence for an active involvement of B-cells in GCA and PMR.<br /> (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Cell Movement
Chemokine CXCL13 blood
Chemokine CXCL13 physiology
Chemokine CXCL9 blood
Chemokine CXCL9 physiology
Female
Giant Cell Arteritis etiology
Humans
Male
Middle Aged
Polymyalgia Rheumatica etiology
Receptors, CXCR3 blood
Receptors, CXCR3 physiology
Receptors, CXCR5 blood
Receptors, CXCR5 physiology
B-Lymphocytes physiology
Chemokines physiology
Giant Cell Arteritis immunology
Polymyalgia Rheumatica immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9157
- Volume :
- 123
- Database :
- MEDLINE
- Journal :
- Journal of autoimmunity
- Publication Type :
- Academic Journal
- Accession number :
- 34237649
- Full Text :
- https://doi.org/10.1016/j.jaut.2021.102684