Immunogenicity of SARS-CoV-2 mRNA vaccine in solid organ transplant recipients.

Authors :: Holden IK
Bistrup C
Nilsson AC
Hansen JF
Abazi R
Davidsen JR
Poulsen MK
Lindvig SO
Justesen US
Johansen IS
Source :: Journal of internal medicine [J Intern Med] 2021 Dec; Vol. 290 (6), pp. 1264-1267. Date of Electronic Publication: 2021 Aug 09.
Publication Year :: 2021
Abstract: Background: It is currently not well described if a two-dose regimen of a Covid-19 vaccine is sufficient to elicit an immune response in solid organ transplant (SOT) recipients.<br />Results: A total of 80 SOT recipients completed a two-dose regimen with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA vaccine. Only 35.0% (n = 28) were able to mount a positive IgG immune response 6 weeks after the second dose of vaccine.<br />Conclusion: This emphasizes that SOT recipients need continued use of personal protective measures. Future studies need to closely examine the cellular immune response in patients with compromised antibody response to Covid-19 vaccination.<br /> (© 2021 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.)