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Evaluation of a Rapid IgG4 Lateral Flow Dipstick Test to Detect Strongyloides stercoralis Infection in Northeast Thailand.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2021 Jul 08; Vol. 105 (3), pp. 688-691. Date of Electronic Publication: 2021 Jul 08. - Publication Year :
- 2021
-
Abstract
- Strongyloides stercoralis affects more than half a billion people worldwide, and hyperinfection in immunocompromised patients can be fatal. Elimination of this neglected tropical disease requires field-applicable diagnostic tools. We conducted a laboratory evaluation of a lateral flow rapid dipstick test (SsRapid™) using sera samples from a Strongyloides-endemic area in northeast Thailand. Group 1 was S. stercoralis-positive and larvae- and/or antibody-positive (according to the IgG ELISA) (N = 100). Group 2 had negative fecal examination and IgG ELISA results (N = 25). Group 3 had other parasitic infections and negative IgG ELISA results (N = 25). The results showed good diagnostic sensitivity (82%) and excellent specificity (96%). Suggested improvements in the SsRapid™ test include increased diagnostic sensitivity and conversion to the more robust cassette format. Field studies should be performed as well.
- Subjects :
- Animals
Antibodies, Helminth blood
Feces parasitology
Helminth Proteins
Humans
Recombinant Proteins
Sensitivity and Specificity
Serologic Tests
Strongyloidiasis blood
Thailand
Antibodies, Helminth immunology
Immunoglobulin G immunology
Strongyloides stercoralis immunology
Strongyloidiasis diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1476-1645
- Volume :
- 105
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 34237022
- Full Text :
- https://doi.org/10.4269/ajtmh.21-0317