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The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo.
- Source :
-
Nature communications [Nat Commun] 2021 Jul 07; Vol. 12 (1), pp. 4169. Date of Electronic Publication: 2021 Jul 07. - Publication Year :
- 2021
-
Abstract
- Reports of P. vivax infections among Duffy-negative hosts have accumulated throughout sub-Saharan Africa. Despite this growing body of evidence, no nationally representative epidemiological surveys of P. vivax in sub-Saharan Africa have been performed. To overcome this gap in knowledge, we screened over 17,000 adults in the Democratic Republic of the Congo (DRC) for P. vivax using samples from the 2013-2014 Demographic Health Survey. Overall, we found a 2.97% (95% CI: 2.28%, 3.65%) prevalence of P. vivax infections across the DRC. Infections were associated with few risk-factors and demonstrated a relatively flat distribution of prevalence across space with focal regions of relatively higher prevalence in the north and northeast. Mitochondrial genomes suggested that DRC P. vivax were distinct from circulating non-human ape strains and an ancestral European P. vivax strain, and instead may be part of a separate contemporary clade. Our findings suggest P. vivax is diffusely spread across the DRC at a low prevalence, which may be associated with long-term carriage of low parasitemia, frequent relapses, or a general pool of infections with limited forward propagation.
- Subjects :
- Adolescent
Adult
Age Factors
Carrier State diagnosis
Carrier State parasitology
Cross-Sectional Studies
Democratic Republic of the Congo epidemiology
Female
Humans
Malaria, Vivax diagnosis
Malaria, Vivax parasitology
Male
Mass Screening statistics & numerical data
Parasitemia parasitology
Prevalence
Risk Factors
Young Adult
Carrier State epidemiology
Malaria, Vivax epidemiology
Parasitemia epidemiology
Plasmodium vivax isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 34234124
- Full Text :
- https://doi.org/10.1038/s41467-021-24216-3