Back to Search
Start Over
CD163-positive cancer cells are a predictor of a worse clinical course in lung adenocarcinoma.
- Source :
-
Pathology international [Pathol Int] 2021 Oct; Vol. 71 (10), pp. 666-673. Date of Electronic Publication: 2021 Jul 07. - Publication Year :
- 2021
-
Abstract
- CD163 is one of the scavenger receptors expressed on macrophages. However, several immunohistochemical studies have demonstrated that CD163 is also detected on cancer cells, and is associated with a poor prognosis. In the present study, we detected CD163 staining on cancer cells in lung adenocarcinoma and squamous cell carcinoma (SCC), and investigated the relationship between CD163 on cancer cells and the clinical prognosis. CD163 staining was seen in 128 of 342 adenocarcinoma cases and 35 of 103 SCC cases. Among the lung adenocarcinoma cases, the progression-free survival and overall survival were significantly shorter in the CD163 high group than the CD163 low group. A similar trend was observed among the SCC cases, but the difference was not statistically significant. Additionally, a higher number of macrophages was detected in areas with CD163-positive cancer cells when compared to areas with CD163-negative cancer cells. In summary, we found that CD163-positive cancer cells are a predictor of a worse clinical course in lung adenocarcinoma and SCC.<br /> (© 2021 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Adenocarcinoma of Lung metabolism
Adenocarcinoma of Lung mortality
Adenocarcinoma of Lung pathology
Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung metabolism
Carcinoma, Non-Small-Cell Lung mortality
Carcinoma, Non-Small-Cell Lung pathology
Carcinoma, Squamous Cell diagnosis
Carcinoma, Squamous Cell metabolism
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell pathology
Case-Control Studies
Cell Line, Tumor
Female
Humans
Lung Neoplasms metabolism
Lung Neoplasms mortality
Lung Neoplasms pathology
Male
Middle Aged
Prognosis
Survival Analysis
Adenocarcinoma of Lung diagnosis
Antigens, CD metabolism
Antigens, Differentiation, Myelomonocytic metabolism
Biomarkers, Tumor metabolism
Carcinoma, Non-Small-Cell Lung diagnosis
Lung Neoplasms diagnosis
Receptors, Cell Surface metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1827
- Volume :
- 71
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Pathology international
- Publication Type :
- Academic Journal
- Accession number :
- 34231937
- Full Text :
- https://doi.org/10.1111/pin.13144