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FosL1 Regulates Regional Metastasis of Head and Neck Squamous Cell Carcinoma by Promoting Cell Migration, Invasion, and Proliferation.
- Source :
-
Anticancer research [Anticancer Res] 2021 Jul; Vol. 41 (7), pp. 3317-3326. - Publication Year :
- 2021
-
Abstract
- Background/aim: We evaluated the impact of FosL1, a member of the activated protein-1 family, on the pathways leading to regional metastasis of head and neck squamous cell carcinoma (HNSCC).<br />Materials and Methods: We examined the influence of small interfering RNA (siRNA) and short heparin RNA (shRNA) mediated knockdown of FosL1 on cell migration, invasion, and proliferation in vitro as well as on regional metastasis in vivo. The prognostic significance of FosL1 was also analyzed using the Kaplan- Meier plotter using data from an HNSCC patient database.<br />Results: Down-regulation of FosL1 inhibited cell migration, invasion, and proliferation in vitro, decreased the incidence of regional metastases, and prolonged the survival of mice in vivo. We also determined that HNSCC patients with higher expression levels of FosL1 had a significantly shorter survival time than those with low expression of FosL1.<br />Conclusion: FosL1 plays a crucial role in promoting cell migration, invasion, and proliferation in HNSCC.<br /> (Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Animals
Cell Line, Tumor
Down-Regulation genetics
Humans
Lymphatic Metastasis genetics
Lymphatic Metastasis pathology
Mice
Mice, Nude
Neoplasm Invasiveness pathology
Prognosis
RNA, Small Interfering genetics
Squamous Cell Carcinoma of Head and Neck pathology
Cell Movement genetics
Cell Proliferation genetics
Neoplasm Invasiveness genetics
Proto-Oncogene Proteins c-fos genetics
Squamous Cell Carcinoma of Head and Neck genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 41
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 34230127
- Full Text :
- https://doi.org/10.21873/anticanres.15119