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Solution blow spinning of PLLA/hydroxyapatite composite scaffolds for bone tissue engineering.
- Source :
-
Biomedical materials (Bristol, England) [Biomed Mater] 2021 Jul 20; Vol. 16 (5). Date of Electronic Publication: 2021 Jul 20. - Publication Year :
- 2021
-
Abstract
- Composite poly-L-lactide acid-based scaffolds with hydroxyapatite (HAp) content up to 75 wt.% were fabricated via solution blow spinning. The influence of HAp concentration on structure, wettability, mechanical properties and chemical and phase composition of the produced materials was examined. It was found that with an increase of HAp content the average fiber diameter was increased, the uniaxial strength and relative elongation were reduced, while the phase composition and surface wettability did not change. The performance of the scaffolds during implantation in the parietal bone of a rat skull for a period from 15 to 90 days was studied. The materials have shown high ability to integrate with both soft and hard tissues. It was found that scaffolds with 25 wt.% HAp content significantly enhance osteogenesis during scarification (damage) of the periosteum. Overall, the fabricated scaffolds proved to be highly efficient for replacing bone defects in long tubular bones.<br /> (© 2021 IOP Publishing Ltd.)
- Subjects :
- Animals
Biotechnology methods
Bone Substitutes chemistry
Bone Substitutes pharmacology
Bone and Bones drug effects
Male
Rats
Rats, Wistar
Durapatite chemistry
Durapatite pharmacology
Osteogenesis drug effects
Polyesters chemistry
Polyesters pharmacology
Tissue Engineering methods
Tissue Scaffolds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1748-605X
- Volume :
- 16
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biomedical materials (Bristol, England)
- Publication Type :
- Academic Journal
- Accession number :
- 34229311
- Full Text :
- https://doi.org/10.1088/1748-605X/ac11ca