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Real-time Tracking and Sensing of Cu + and Cu 2+ with a Single SERS Probe in the Live Brain: Toward Understanding Why Copper Ions Were Increased upon Ischemia.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Sep 20; Vol. 60 (39), pp. 21351-21359. Date of Electronic Publication: 2021 Aug 18. - Publication Year :
- 2021
-
Abstract
- The imbalance of Cu <superscript>+</superscript> and Cu <superscript>2+</superscript> in the brain is closely related to neurodegenerative diseases. However, it still lacks of effective analytical methods for simultaneously determining the concentrations of Cu <superscript>+</superscript> and Cu <superscript>2+</superscript> . Herein, we created a novel SERS probe (CuSP) to real-time track and accurately quantify extracellular concentrations of Cu <superscript>+</superscript> and Cu <superscript>2+</superscript> in the live brain. The present CuSP probe demonstrated specific ability for recognition of Cu <superscript>+</superscript> and Cu <superscript>2+</superscript> in a dual-recognition mode. Then, a microarray consisting of 8 CuSP probes with high tempo-spatial resolution and good accuracy was constructed for tracking and simultaneously biosensing of Cu <superscript>+</superscript> and Cu <superscript>2+</superscript> in the cerebral cortex of living brain. Using our powerful tool, it was found that that the concentrations of Cu <superscript>2+</superscript> and Cu <superscript>+</superscript> were increased by ≈4.26 and ≈1.80 times upon ischemia, respectively. Three routes were first discovered for understanding the mechanisms of the increased concentrations of Cu <superscript>+</superscript> and Cu <superscript>2+</superscript> during ischemia.<br /> (© 2021 Wiley-VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 60
- Issue :
- 39
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 34228388
- Full Text :
- https://doi.org/10.1002/anie.202106193