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Utilization of Magnesium for the Treatment of Chronic Pain.

Authors :: Urits I
Jung JW
Amgalan A
Fortier L
Anya A
Wesp B
Orhurhu V
Cornett EM
Kaye AD
Imani F
Varrassi G
Liu H
Viswanath O
Source :: Anesthesiology and pain medicine [Anesth Pain Med] 2021 Feb 06; Vol. 11 (1), pp. e112348. Date of Electronic Publication: 2021 Feb 06 (Print Publication: 2021).
Publication Year :: 2021
Abstract: Context: The International Association for the Study of Pain (IASP) defines chronic pain as pain that persists or recurs for longer than 3 months. Chronic pain has a significant global disease burden with profound effects on health, quality of life, and socioeconomic costs. Evidence Acquisition: Narrative review. Results: There are several treatment options, including pharmacological therapy, physical rehabilitation, psychological therapies, and surgical interventions, for chronic pain management. Magnesium has been FDA-approved for several indications including hypomagnesemia, arrhythmia, prevention of seizures in eclampsia/preeclampsia, and constipation. Magnesium has been used for numerous off-label uses, notably for acute and chronic pain management. The mechanism of magnesium in pain management is primarily through its action as a voltage-gated antagonist of NMDA receptors, which are involved in pain transduction. Conclusions: This narrative review will focus on the current evidence and data surrounding the utilization of magnesium as a treatment option for chronic pain. Competing Interests: Conflict of Interests: None. (Copyright © 2021, Author(s).)