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Covid-19 and Growth Hormone/Insulin-Like Growth Factor 1: Study in Critically and Non-Critically Ill Patients.
- Source :
-
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 Jun 16; Vol. 12, pp. 644055. Date of Electronic Publication: 2021 Jun 16 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Objective: We aimed to measure insulin-like growth factor 1 (IGF1) and growth hormone (GH) in critically and non-critically ill patients with Covid-19 and assess them vis-a-vis clinical and laboratory parameters and prognostic tools.<br />Subjects and Methods: We included patients who were admitted to the wards or the ICU of the largest Covid-19 referral hospital in Greece; patients with non-Covid-19 pneumonia served as controls. Apart from the routine laboratory work-up for Covid-19 we measured GH and IGF1 (and calculated normalized IGF-1 values as standard deviation scores; SDS), after blood sampling upon admission to the wards or the ICU.<br />Results: We studied 209 critically and non-critically ill patients with Covid-19 and 39 control patients. Patients with Covid-19 who were ICU non-survivors were older and presented with a worse hematological/biochemical profile (including white blood cell count, troponin, glucose, aminotransferases and lactate dehydrogenase) compared to ICU survivors or Covid-19 survivors in the wards. Overall, IGF-1 SDS was higher in Covid-19 survivors compared to non-survivors (-0.96 ± 1.89 vs -2.05 ± 2.48, respectively, p=0.030). No significant differences were noted in GH between the groups. Nevertheless, in critically ill patients with Covid-19, the prognostic value of IGF-1 (raw data), IGF-1 (SDS) and GH for survival/non-survival was on a par with that of APACHE II and SOFA (with a marginal difference between GH and SOFA).<br />Conclusion: In conclusion, our findings suggest that there might be an association between low IGF1 (and possibly GH) and poor outcome in patients with Covid-19.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Ilias, Diamantopoulos, Botoula, Athanasiou, Zacharis, Tsipilis, Jahaj, Vassiliou, Vassiliadi, Kotanidou, Tsagarakis and Dimopoulou.)
- Subjects :
- Adult
Aged
Aged, 80 and over
COVID-19 diagnosis
COVID-19 mortality
Case-Control Studies
Female
Greece epidemiology
Hospitalization statistics & numerical data
Humans
Intensive Care Units statistics & numerical data
Male
Middle Aged
Prognosis
SARS-CoV-2 physiology
Severity of Illness Index
Survivors statistics & numerical data
COVID-19 metabolism
COVID-19 pathology
Critical Illness mortality
Human Growth Hormone metabolism
Insulin-Like Growth Factor I metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1664-2392
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 34220703
- Full Text :
- https://doi.org/10.3389/fendo.2021.644055