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Diseases associated with hypercobalaminemia in dogs in United Kingdom: A retrospective study of 47 dogs.

Authors :
Da Riz F
Higgs P
Ruiz G
Source :
The Canadian veterinary journal = La revue veterinaire canadienne [Can Vet J] 2021 Jun; Vol. 62 (6), pp. 611-616.
Publication Year :
2021

Abstract

Cobalamin concentration is often assessed in clinical practice but little is known about the significance of hypercobalaminemia. The objective of this retrospective study was to identify the conditions associated with hypercobalaminemia in dogs and to investigate association with clinicopathological variables. Medical records of dogs having serum cobalamin measured between 2016 and 2018 were reviewed. One hundred sixty dogs were included and 47 (29%) showed hypercobalaminemia. Dogs with hypercobalaminemia had gastrointestinal (57%), hepatic (11%), neurological (11%), endocrine (9%), renal (4%), pancreatic (2%), and miscellaneous (6%) diseases. Overall, 11% had neoplasia. This distribution was not significantly different from that for hypocobalaminemic and normocobalaminemic dogs. There were significantly more dogs with hyperfolatemia in the hypercobalaminemia group. These results suggest that in clinical practice hypercobalaminemia is commonly identified in gastrointestinal and hepatic disease in dogs, but can also be seen with endocrine and neurological conditions. The frequency of hyperfolatemia alongside hypercobalaminemia may reflect common metabolic pathways.<br /> (Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.)

Details

Language :
English
ISSN :
0008-5286
Volume :
62
Issue :
6
Database :
MEDLINE
Journal :
The Canadian veterinary journal = La revue veterinaire canadienne
Publication Type :
Academic Journal
Accession number :
34219769