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Methods to improve the immunogenicity of plasmid DNA vaccines.
- Source :
-
Drug discovery today [Drug Discov Today] 2021 Nov; Vol. 26 (11), pp. 2575-2592. Date of Electronic Publication: 2021 Jun 30. - Publication Year :
- 2021
-
Abstract
- DNA vaccines have emerged as innovative approaches that have great potential to overcome the limitations of current conventional vaccines. Plasmid DNA vaccines are often safer than other vaccines because they carry only antigen genetic information, are more stable and easier to produce, and can stimulate both humoral and cellular immune responses. Although the results of ongoing clinical trials are very promising, some limitations compromise the immunogenicity of these vaccines. Thus, this review describes different strategies that can be explored to improve the immunogenicity of plasmid DNA vaccines, including the optimization of the plasmid vector backbone, the use of different methods for vaccine delivery, the use of alternative administration routes and the inclusion of adjuvants. In combination, these improvements could lead to the successful clinical use of plasmid DNA vaccines.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Subjects :
- Administration, Intravenous
Administration, Mucosal
Antigen-Presenting Cells
Biolistics
Drug Administration Routes
Electroporation
Humans
Injections, Intradermal
Injections, Intramuscular
Injections, Subcutaneous
Liposomes
Plasmids
Vaccines, DNA therapeutic use
Adjuvants, Vaccine therapeutic use
Immunogenicity, Vaccine
Vaccines, DNA administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5832
- Volume :
- 26
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Drug discovery today
- Publication Type :
- Academic Journal
- Accession number :
- 34214667
- Full Text :
- https://doi.org/10.1016/j.drudis.2021.06.008