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Parvaxanthines D-F and Asponguanosines C and D, Racemic Natural Hybrids from the Insect Cyclopelta parva .
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 09; Vol. 26 (12). Date of Electronic Publication: 2021 Jun 09. - Publication Year :
- 2021
-
Abstract
- Five new compounds including three pairs of enantiomeric xanthine analogues, parvaxanthines D-F ( 1 - 3 ), two new guanosine derivatives, asponguanosines C and D ( 6 and 7 ), along with two known adenine derivatives were isolated from the insect Cyclopelta parva . Racemic 1 - 3 were further separated by chiral HPLC. Their absolute configurations were assigned by spectroscopic and computational methods. It is interesting that all of these isolates are natural product hybrids. Antiviral, immunosuppressive, antitumor and anti-inflammatory properties of all the isolates were evaluated.
- Subjects :
- Animals
Biological Products chemistry
Cells, Cultured
Chlorocebus aethiops
Chromatography, High Pressure Liquid methods
Mice
Mice, Inbred C57BL
Molecular Structure
Stereoisomerism
Anti-Inflammatory Agents pharmacology
Antineoplastic Agents pharmacology
Antiviral Agents pharmacology
Biological Products pharmacology
Guanosine chemistry
Insecta chemistry
Xanthines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 26
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 34207872
- Full Text :
- https://doi.org/10.3390/molecules26123531