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Successful Treatment of Staphylococcus aureus Prosthetic Joint Infection with Bacteriophage Therapy.
- Source :
-
Viruses [Viruses] 2021 Jun 21; Vol. 13 (6). Date of Electronic Publication: 2021 Jun 21. - Publication Year :
- 2021
-
Abstract
- Successful joint replacement is a life-enhancing procedure with significant growth in the past decade. Prosthetic joint infection occurs rarely; it is a biofilm-based infection that is poorly responsive to antibiotic alone. Recent interest in bacteriophage therapy has made it possible to treat some biofilm-based infections, as well as those caused by multidrug-resistant pathogens, successfully when conventional antibiotic therapy has failed. Here, we describe the case of a 61-year-old woman who was successfully treated after a second cycle of bacteriophage therapy administered at the time of a two-stage exchange procedure for a persistent methicillin-sensitive Staphylococcus aureus (MSSA) prosthetic knee-joint infection. We highlight the safety and efficacy of both intravenous and intra-articular infusions of bacteriophage therapy, a successful outcome with a single lytic phage, and the development of serum neutralization with prolonged treatment.
- Subjects :
- Bacteriophages classification
Biofilms growth & development
Female
Humans
Methicillin-Resistant Staphylococcus aureus pathogenicity
Methicillin-Resistant Staphylococcus aureus virology
Middle Aged
Prosthesis-Related Infections microbiology
Arthritis, Infectious therapy
Bacteriophages physiology
Phage Therapy methods
Prosthesis-Related Infections therapy
Staphylococcal Infections therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1999-4915
- Volume :
- 13
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Viruses
- Publication Type :
- Report
- Accession number :
- 34205687
- Full Text :
- https://doi.org/10.3390/v13061182