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Sugar Fructose Triggers Gut Dysbiosis and Metabolic Inflammation with Cardiac Arrhythmogenesis.

Authors :
Cheng WL
Li SJ
Lee TI
Lee TW
Chung CC
Kao YH
Chen YJ
Source :
Biomedicines [Biomedicines] 2021 Jun 25; Vol. 9 (7). Date of Electronic Publication: 2021 Jun 25.
Publication Year :
2021

Abstract

Fructose is a main dietary sugar involved in the excess sugar intake-mediated progression of cardiovascular diseases and cardiac arrhythmias. Chronic intake of fructose has been the focus on the possible contributor to the metabolic diseases and cardiac inflammation. Recently, the small intestine was identified to be a major organ in fructose metabolism. The overconsumption of fructose induces dysbiosis of the gut microbiota, which, in turn, increases intestinal permeability and activates host inflammation. Endotoxins and metabolites of the gut microbiota, such as lipopolysaccharide, trimethylamine N-oxide, and short-chain fatty acids, also influence the host inflammation and cardiac biofunctions. Thus, high-fructose diets cause heart-gut axis disorders that promote cardiac arrhythmia. Understanding how gut microbiota dysbiosis-mediated inflammation influences the pathogenesis of cardiac arrhythmia may provide mechanisms for cardiac arrhythmogenesis. This narrative review updates our current understanding of the roles of excessive intake of fructose on the heart-gut axis and proposes potential strategies for inflammation-associated cardiac vascular diseases.

Details

Language :
English
ISSN :
2227-9059
Volume :
9
Issue :
7
Database :
MEDLINE
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
34201938
Full Text :
https://doi.org/10.3390/biomedicines9070728